NEW AMINOALKANOL COMPOUNDS

NEW AMINOALKANOL COMPOUNDS

1-(3,4-Dimethoxyphenethylamino)-3-(substituted phenoxy)-2-propanols; and acid-addition salts. The substituent in the 3-(substituted phenoxy) group can be lower alkoxy, chloro, cyano, hydroxymethyl, acetyl, m-lower alkyl, or o-allyl. The compounds are pharmacological agents, especially beta-adrenergi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ROBERT FREDERICK MEYER, ANN HOLMES
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:1-(3,4-Dimethoxyphenethylamino)-3-(substituted phenoxy)-2-propanols; and acid-addition salts. The substituent in the 3-(substituted phenoxy) group can be lower alkoxy, chloro, cyano, hydroxymethyl, acetyl, m-lower alkyl, or o-allyl. The compounds are pharmacological agents, especially beta-adrenergic blocking agents with cardio-selective activity. They can be produced by reacting a 1-halo-3-(substituted phenoxy)-2-propanol with 3,4-dimethoxyphenethylamine; or by reacting a 1,2-epoxy-3-(substituted phenoxy)propane with 3,4-dimethoxyphenethylamine. Starting materials for use in those processes are obtained by reacting a phenol or a sodium phenolate with epichlorohydrin under varying conditions.