Crystalline trimetrexate salts and the process for making the same

The present invention provides for a crystalline form of trimetrexate either as a glucuronate, acetate, hydrochloride, methanosulfonate or lactate salt, which can be processed galenically as a stable, well-defined solid substance and processes for producing the crystalline forms. Such crystalline fo...

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Hauptverfasser: PAUL E KENNEDY, DR KURT-HENNING AHRENS, JOHANN P MORSDORF, INGOMAR GRAFE
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention provides for a crystalline form of trimetrexate either as a glucuronate, acetate, hydrochloride, methanosulfonate or lactate salt, which can be processed galenically as a stable, well-defined solid substance and processes for producing the crystalline forms. Such crystalline forms allow for prolonged stability in storage and for oral and intravenous administration of the drug.