Proteasomal activity

The present invention relates to modulation and/or regulation of proteasomal activity. The invention provides assay methods for identifying compounds which inhibit viral replication and pathogenesis, for identifying inhibitors of the nuclease-inhibitory function of the human immunodeficiency virus T...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	FRANCK PETIT, HANS-PETER SCHMID, ANNE-SOPHIE JARROUSSE, KARINE GAUTIER, PETER-MICHAEL KLOETZEL, PAUL NICOLAS, SAID MOUZEYAR, SALOUA BADAOUI
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to modulation and/or regulation of proteasomal activity. The invention provides assay methods for identifying compounds which inhibit viral replication and pathogenesis, for identifying inhibitors of the nuclease-inhibitory function of the human immunodeficiency virus TAT protein, for identifying inhibitors of the protease-inhibitory function of the human immunodeficiency virus TAT protein, for identifying compounds which change the concentrations of regulatory proteins by modulating the rate of proteasomal destruction of specific mRNAs, and methods for generating resistance to bacterial or viral infection damage. The invention provides assays, kits for carrying out said assays, compounds identified by said assays, together with amino acid sequences encoding said compounds and medicinal compositions derived therefrom. Where legally permissible the invention also provides methods of treatment based on the modulation/regulation of proteasomal activity.