Hiv integrase inhibitors

Hiv integrase inhibitors

Certain six-membered aromatic and heteroaromatic-dioxo-butyric acid derivatives are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutical...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: STEVEN D. YOUNG, JUAN JAEN, LINDA S PAYNE, JOHN S. WAI, JAMES P. GUARE, MELISSA EGBERTSON, LINGHANG ZHUANG, MARK W. EMBREY, THORSTEN E FISHER, JOSEPH P. VACCA, DAVID L CLARK, LEE TRAN, MARIE LANGFORD, JULIO C. MEDINA, JEFFREY MELAMED
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Certain six-membered aromatic and heteroaromatic-dioxo-butyric acid derivatives are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.