Nonclassical pyrrolo{2,3-d}pyrimidine antifolates

Nonclassical pyrrolo[2,3-d]pyrimidine antifolates are described and claimed. Also described and claimed is a rapid analog process which enables a quick work-up of the antifolate which avoids costly and time-consuming chromatographic separation techniques. Also described and claimed are methods of tr...

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Hauptverfasser:	CHRISTOPHER L. JORDAN, DANIEL J. SOOSE, VINOD F. PATEL
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Nonclassical pyrrolo[2,3-d]pyrimidine antifolates are described and claimed. Also described and claimed is a rapid analog process which enables a quick work-up of the antifolate which avoids costly and time-consuming chromatographic separation techniques. Also described and claimed are methods of treating susceptible neoplasms with these nonclassical antifolates. Also described and claimed are methods of treating psoriasis and arthritis with these nonclassical antifolates.