Process for the preparation of furosemide

Process for the preparation of furosemide

PCT No. PCT/EP95/04153 Sec. 371 Date Apr. 23, 1997 Sec. 102(e) Date Apr. 23, 1997 PCT Filed Oct. 23, 1995 PCT Pub. No. WO96/12714 PCT Pub. Date May 2, 1996A new process for the preparation of furosemide [4-chloro-N-(2-furylmethyl)-5-sulfamoyl-anthranilic acid]comprising the photochlorination of 4-ch...

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Hauptverfasser: GIOVANNI SIGNOR, ANGELO SIGNOR, ALFREDO GUERRATO
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:PCT No. PCT/EP95/04153 Sec. 371 Date Apr. 23, 1997 Sec. 102(e) Date Apr. 23, 1997 PCT Filed Oct. 23, 1995 PCT Pub. No. WO96/12714 PCT Pub. Date May 2, 1996A new process for the preparation of furosemide [4-chloro-N-(2-furylmethyl)-5-sulfamoyl-anthranilic acid]comprising the photochlorination of 4-chloro-2-fluoro-toluene to give 4-chloro-2-fluoro-benzotrichloride, the aminosulfonylation of the same and the subsequent condensation with furfurylamine.