Fibrinogen receptor antagonists

Fibrinogen receptor antagonists

The present invention relates to novel fibrinogen receptor antagonists labelled with a detectable atom, which have a comparable or higher affinity for the receptor than I-fibrinogen and whose binding is not impaired by foreign proteins, in particular the tritium-labelled fibrinogen receptor antagoni...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: KARL-HEINZ SWITEK, FRANK HIMMELSBACH, JOHANNES WEISENBERGER, GUNTER LINZ, HANS-DIETER SCHUBERT
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
TESTING
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Beschreibung
Zusammenfassung:The present invention relates to novel fibrinogen receptor antagonists labelled with a detectable atom, which have a comparable or higher affinity for the receptor than I-fibrinogen and whose binding is not impaired by foreign proteins, in particular the tritium-labelled fibrinogen receptor antagonists according to Claim 3 which, in the presence of foreign protein, e.g. of albumin or of fibrinogen, have an affinity (KD) of less than 500 nM for the receptor, their use as ligands in the fibrinogen receptor binding test or for determination of the concentration of fibrinogen receptor antagonists, and to processes for their production.