Amidinoindoles, amidinoazoles, and analogs thereof as inhibitors of factor xa and of thrombin

The present application describes amidinoindoles, amidinoazoles, and analogs thereof of formula (I): wherein W, W , W , and W are selected from CH and N, provided that one of W and W is C(C(=NH)NH2) and at most two of W, W , W , and W are N and one of J and J is substituted by -(CH2)n-Z-A-B, which a...

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Hauptverfasser:	N QI HAN, RUTH RICHMOND WEXLER, CELIA DOMINGUEZ, DANIEL EMMETT DUFFY, KAREN ANITA ROSSI, MIMI LIFEN QUAN, JEONGSOOK MARIA PARK
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	N QI HAN RUTH RICHMOND WEXLER CELIA DOMINGUEZ DANIEL EMMETT DUFFY KAREN ANITA ROSSI MIMI LIFEN QUAN JEONGSOOK MARIA PARK
description	The present application describes amidinoindoles, amidinoazoles, and analogs thereof of formula (I): wherein W, W , W , and W are selected from CH and N, provided that one of W and W is C(C(=NH)NH2) and at most two of W, W , W , and W are N and one of J and J is substituted by -(CH2)n-Z-A-B, which are useful as inhibitors of factor Xa or thrombin.
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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	Amidinoindoles, amidinoazoles, and analogs thereof as inhibitors of factor xa and of thrombin
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