Amidinoindoles, amidinoazoles, and analogs thereof as inhibitors of factor xa and of thrombin

The present application describes amidinoindoles, amidinoazoles, and analogs thereof of formula (I): wherein W, W , W , and W are selected from CH and N, provided that one of W and W is C(C(=NH)NH2) and at most two of W, W , W , and W are N and one of J and J is substituted by -(CH2)n-Z-A-B, which a...

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Hauptverfasser:	N QI HAN, RUTH RICHMOND WEXLER, CELIA DOMINGUEZ, DANIEL EMMETT DUFFY, KAREN ANITA ROSSI, MIMI LIFEN QUAN, JEONGSOOK MARIA PARK
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	The present application describes amidinoindoles, amidinoazoles, and analogs thereof of formula (I): wherein W, W , W , and W are selected from CH and N, provided that one of W and W is C(C(=NH)NH2) and at most two of W, W , W , and W are N and one of J and J is substituted by -(CH2)n-Z-A-B, which are useful as inhibitors of factor Xa or thrombin.