PREPARATION OF SUBSTITUTED COBAMIDES

PREPARATION OF SUBSTITUTED COBAMIDES

1306958 Substituted cobamides PIERREL SpA 2 Sept 1971 [30 Sept 1970] 46545/70 Heading C2V In a process for the preparation of α-(5,6- dimethylbenziminazolyl) - methyl - cobamide a solution of α-(5,6-dimethylbenziminazolyl)- hydroxy-cobarnide is exposed to white light while being reduced with stannou...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: GIANCARLO MANCINI, GERARDO FABRIZIO
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Zusammenfassung:1306958 Substituted cobamides PIERREL SpA 2 Sept 1971 [30 Sept 1970] 46545/70 Heading C2V In a process for the preparation of α-(5,6- dimethylbenziminazolyl) - methyl - cobamide a solution of α-(5,6-dimethylbenziminazolyl)- hydroxy-cobarnide is exposed to white light while being reduced with stannous chloride in an inert atmosphere, the resulting solution under nitrogen and away from light is passed through an anionic exchange resin to remove impurities, then reacted with a methyl halide to obtain the methyl derivative which is absorbed on a non-ionic resin in a column, eluted and the final product crystallized from the eluate. An example is given.