A process for the preparation of quetiapine and intermediates therefor

A process for the preparation of quetiapine and intermediates therefor

The invention refers to a novel process for the preparation of 11-[4-/2-(2-hydroxyethoxy)ethyl/-1-piperazinyl]dibenzo[b,f]-1,4-thiazepine of the formula (I) known as quetiapine. According to the invention, a haloethylpiperazinylthiazepine derivative of the formula (VIII), wherein Hal stands for a ha...

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Hauptverfasser: GYULA SIMIG, GYORGY KRASZNAI, KALMAN NAGY, GYORGYI KOVANYINE LAX, PETER TOMPE, GYORGYNE RAKOCZY, DANIEL BOZSING, GYORGYI VERECZKEYNE DONATH
Format: Patent
Sprache:eng
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Zusammenfassung:The invention refers to a novel process for the preparation of 11-[4-/2-(2-hydroxyethoxy)ethyl/-1-piperazinyl]dibenzo[b,f]-1,4-thiazepine of the formula (I) known as quetiapine. According to the invention, a haloethylpiperazinylthiazepine derivative of the formula (VIII), wherein Hal stands for a halo atom, is reacted with ethylene glycol.