Dithiocarbonimidate derivatives

Dithiocarbonimidate derivatives

Dithiocarbonimidate derivatives of general formula (1), prodrugs thereof, or pharmaceutically acceptable salts of both, useful as organ or tissue fibroplasia inhibitors and other drugs wherein R is alkyl, alkenyl, alkynyl, or cycloalkyl; E is C1-C5 alkylene, C3-C5 alkenylene, or C3-C5 alkynylene; A...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: TSUTOMU NAKAGAWA, HIROSHI YAMAGA, W. EWAN HUME, TERUHISA TOKUNAGA, RYU NAGATA, MUTSUO TAIJI
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Dithiocarbonimidate derivatives of general formula (1), prodrugs thereof, or pharmaceutically acceptable salts of both, useful as organ or tissue fibroplasia inhibitors and other drugs wherein R is alkyl, alkenyl, alkynyl, or cycloalkyl; E is C1-C5 alkylene, C3-C5 alkenylene, or C3-C5 alkynylene; A is nitrogenous heteroaryl or a group represented by general formula (2) (wherein R is hydrogen or a substituent; and R is hydroxyl, alkoxy, alkenyloxy, alkynyloxy, or -NR R ); and Ar is aryl or heteroaryl.