N,N-DI-ALKYL(PHENOXY)BENZAMIDE DERIVATIVES

N,N-DI-ALKYL(PHENOXY)BENZAMIDE DERIVATIVES

The present invention relates to compounds of the formula: and the pharmaceutically acceptable salts thereof, wherein Z can be: (a) wherein R3 is alkyl having 1 to 6 carbon atoms and, when n is greater than 1, each R3 can be the same or different; and n is an integer from 1 to 3; R1 and R2 can each...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MICHAEL ALLAN STEALEY, ROGER ANTHONY NOSAL, RICHARD MATHIAS WEIER
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to compounds of the formula: and the pharmaceutically acceptable salts thereof, wherein Z can be: (a) wherein R3 is alkyl having 1 to 6 carbon atoms and, when n is greater than 1, each R3 can be the same or different; and n is an integer from 1 to 3; R1 and R2 can each independently be hydrogen, straight or branched chain alkyl, or cycloalkyl having 3 to 8 carbon atoms which can optionally be substituted at one or more positions by alkyl of 1 to 6 carbon atoms; X is oxygen, sulfur, NR4, wherein R4 is hydrogen or alkyl having 1 to 4 carbon atoms, C=O, CHOH, or CH2; Y is hydrogen, alkoxy, halogen, alkyl, or hydroxy; and m is an integer from 0 to 3. The compounds are antagonists of platlet-activating factor (PAF).