Liposome composition and method for administration of a radiosensitizer

A method for administering a radiosensitizer to a tumor site in a subject is described. The method includes preparing liposomes composed of a vesicle-forming lipid and a lipid-derivatized radiosensitizer. In one embodiment, the radiosensitizer is dipalmitoyl-5-iodo-2'-deoxyuridine. A method for...

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Bibliographische Detailangaben
Hauptverfasser: KRISTEN M. HJORTSVANG, PAUL S USTER, ADAM A. ZETTER, GEORGE Z. ZHU, JAMES L SLATER
Format: Patent
Sprache:eng
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Zusammenfassung:A method for administering a radiosensitizer to a tumor site in a subject is described. The method includes preparing liposomes composed of a vesicle-forming lipid and a lipid-derivatized radiosensitizer. In one embodiment, the radiosensitizer is dipalmitoyl-5-iodo-2'-deoxyuridine. A method for preparing the liposome composition including the lipid-derivatized radiosensitizer is also disclosed.