NOVEL HMG-COA REDUCTASE INHIBITORS

Disclosed are novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors useful as antihypercholesterolemic agents represented by the formula and the corresponding ring-opened hydroxy acids derived therefrom and pharmaceutically acceptable salts thereof. Pharmaceutical compositions containing...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: KENT W. NEUENSCHWANDER, JOHN R. REGAN, BENEDICT J. KOSMIDER, ANTHONY C. SCOTESE
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:Disclosed are novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors useful as antihypercholesterolemic agents represented by the formula and the corresponding ring-opened hydroxy acids derived therefrom and pharmaceutically acceptable salts thereof. Pharmaceutical compositions containing said compounds and method of inhibiting the biosynthesis of cholesterol therewith are also disclosed.