Polymeric immunoglobulin receptor (pigr)-binding domains and methods of use therefor

The present invention identifies a domain located in the C alpha 3 domain of IgA that is reponsible for targeting of the polymeric immunoglobulin receptor (pIgR) and transport of the antibody to the mucosal epithelium. This pIgR-binding domain may be used to target a wide variety of compositions, in...

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Bibliographische Detailangaben
Hauptverfasser:	J. MARK HEXHAM, J. DONALD CAPRA, KENDRA WHITE, WLODECK MANDECKI
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMBINATORIAL CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention identifies a domain located in the C alpha 3 domain of IgA that is reponsible for targeting of the polymeric immunoglobulin receptor (pIgR) and transport of the antibody to the mucosal epithelium. This pIgR-binding domain may be used to target a wide variety of compositions, including proteins, nucleic acids, drugs and diagnositic agents, to the mucosal surface. Other more specific targeting agents may be used in conjunction with the pIgR-binding domain to define further the ultimate localization of the complexes in the body. Treatment of a large number of disease conditions such as viral, fungal and bacterial infections, as well as cancer, may be improved through the use of a pIgR-binding domain.