Processes of making and crystalline forms of a MDM2 inhibitor

Processes of making and crystalline forms of a MDM2 inhibitor

The present invention provides processes for making 2-((3R,5R,6S)-5-(3 5 chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3 methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BIO, Matthew, FOX, Brian M, COCHRAN, Brian, FANG, Yuanqing, CAILLE, Sebastien, LUCAS, Brian S, WIEDEMANN, Sean, MCGEE, Lawrence R, VOUNATSOS, Filisaty, WORTMAN, Sarah
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention provides processes for making 2-((3R,5R,6S)-5-(3 5 chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3 methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.