Multispecific binding proteins targeting CAIX, ANO1, mesothelin, TROP2, CEA, or claudin-18.2

Multispecific binding proteins targeting CAIX, ANO1, mesothelin, TROP2, CEA, or claudin-18.2

MULTISPECIFIC BINDING PROTEINS TARGETING CAIX, ANO1, MESOTHELIN, TROP2, CEA, OR CLAUDIN-18.2 Multi-specific binding proteins that bind the NKG2D receptor, CD16, and a tumor 5 associated antigen selected from carbonic anhydrase 9 (CAIX), anoctamin-1 (ANOI), mesothelin, TROP2, CEA and claudin-18.2 are...

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Bibliographische Detailangaben
Hauptverfasser: CHANG, Gregory P, PRINZ, Bianka, GUTIERREZ, Eva, CHEUNG, Ann F, HANEY, William, LUNDE, Bradley M
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:MULTISPECIFIC BINDING PROTEINS TARGETING CAIX, ANO1, MESOTHELIN, TROP2, CEA, OR CLAUDIN-18.2 Multi-specific binding proteins that bind the NKG2D receptor, CD16, and a tumor 5 associated antigen selected from carbonic anhydrase 9 (CAIX), anoctamin-1 (ANOI), mesothelin, TROP2, CEA and claudin-18.2 are described, as well as pharmaceutical compositions and therapeutic methods useful for the treatment of cancer.