NEUTRALIZING ANTI-INFLUENZA B ANTIBODIES AND USES THEREOF

Abstract The invention relates to antibodies and antigen binding fragments thereof that are capable of binding to influenza B virus hemagglutinin (HA) and neutralizing influenza B virus in two phylogenetically distinct lineages. In one embodiment, the antibody or antigen binding fragment is capable...

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Bibliographische Detailangaben
Hauptverfasser: Lanzavecchia, Antonio, Kallewaard-Lelay, Nicole, McAuliffe, Josephine Mary, Yuan, Andy, Benjamin, Ebony, Wachter, Leslie, Corti, Davide, Zhu, Qing
Format: Patent
Sprache:eng
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Zusammenfassung:Abstract The invention relates to antibodies and antigen binding fragments thereof that are capable of binding to influenza B virus hemagglutinin (HA) and neutralizing influenza B virus in two phylogenetically distinct lineages. In one embodiment, the antibody or antigen binding fragment is capable of binding to influenza B virus hemagglutinin and neutralizing influenza B virus in Yamagata and Victoria lineages.