P2X7 modulators

The present invention is directed to compounds of Formulas (1, la, lla and lib): o R3 Rf N N "X Formula (1) & Formula (la) o R3 R6 0 R3 Re N Re 8 R N N N-R6 Formula (Ila) Formula (l1b) The invention also relates to pharmaceutical compositions comprising compounds of Formulas (1, la, Ila and...

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Bibliographische Detailangaben
Hauptverfasser:	ANDRES GIL, Jose Ignacio, ALCAZAR VACA, Manuel Jesus, SAVALL, Brad M, CHROVIAN, Christa C, DENG, Xiaohu, SWANSON, Devin M, ALLISON, Brett D, DVORAK, Curt A, LETAVIC, Michael A, COATE, Heather R, STENNE, Brice M, MANI, Neelakandha S, SOYODE-JOHNSON, Akinola, WALL, Jessica L, GELIN, Christine F, DE ANGELIS, Meri, RECH, Jason C, LIANG, Jimmy T
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention is directed to compounds of Formulas (1, la, lla and lib): o R3 Rf N N "X Formula (1) & Formula (la) o R3 R6 0 R3 Re N Re 8 R N N N-R6 Formula (Ila) Formula (l1b) The invention also relates to pharmaceutical compositions comprising compounds of Formulas (1, la, Ila and lIb). Methods of making and using the compounds of Formulas (1, la, Ila and lib) are also within the scope of the invention.