IL-2 muteins for treating autoimmune and inflammatory diseases

IL-2 muteins for treating autoimmune and inflammatory diseases

Provided herein are IL-2 muteins that bind to IL-2 receptor a subunit but do not have measurable binding to IL-2 receptor Psubunit. Also provided are compositions, kits, methods, and uses involving such IL-2 muteins.

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Bibliographische Detailangaben
Hauptverfasser: GEORGIEV, Peter, SRIRAMAN, Venkataraman, BENSO, Lia, JUAN, Veronica M, AZADI, Glareh, HALL, Brian E, MOORE, Renee, ALVES, Stephen E, CHENG, Alan C, ZHANG-HOOVER, Jie, BEAUMONT, Maribel
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Provided herein are IL-2 muteins that bind to IL-2 receptor a subunit but do not have measurable binding to IL-2 receptor Psubunit. Also provided are compositions, kits, methods, and uses involving such IL-2 muteins.