High purity RNA compositions and methods for preparation thereof

High purity RNA compositions and methods for preparation thereof

Abstract The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by inproved processes, in particular, improved in vitro-tr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Nelson, Jennifer, Butora, Gabor, Rabideau, Amy E, Issa, William, Miracco, Edward J, Hoge, Stephen
Format: Patent
Sprache:eng
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:Abstract The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by inproved processes, in particular, improved in vitro-transcription (IVT) processes. The invention also relates to methods for producing and purifying RNA (e.g, therapeutic RNAs), as well as methods for using the RNA compositions and therapeutic applications thereof. WO 2018/053209 PCT/US2017/051674 Figure 40. >) a a) 0 z zn z 0z < < Znn + r'JL ~Ln: Zn -~ ~ 0n fu -a) 0) CL 4-~ " U~ *r 4n