HETEROARYL SUBSTITUTED SPIROPIPERIDINYL DERIVATIVES AND PHARMACEUTICAL USES THEREOF

The present invention provides a compound of formula (1) or a pharmaceutically acceptable salt thereof; N'R1 R4 i wherein R 1 R2 , R 4 and X 1 are defeined herein, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combi...

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Hauptverfasser: CULSHAW, Andrew James, MILTZ, Wolfgang, ROEHN, Till, BUSHABOINA, Mallesh, WÄLCHLI, Rudolf, HURLEY, Timothy Brian, PATEL, Tajesh, CHEN, Xin, SANDHAM, David Andrew, RAJAGOPALAN, Srinivasan, ORAIN, David, THOMA, Gebhard, TICHKULE, Ritesh Bhanudasji, LABBE-GIGUERE, Nancy, CHEUNG, Atwood Kim
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creator CULSHAW, Andrew James
MILTZ, Wolfgang
ROEHN, Till
BUSHABOINA, Mallesh
WÄLCHLI, Rudolf
HURLEY, Timothy Brian
PATEL, Tajesh
CHEN, Xin
SANDHAM, David Andrew
RAJAGOPALAN, Srinivasan
ORAIN, David
THOMA, Gebhard
TICHKULE, Ritesh Bhanudasji
LABBE-GIGUERE, Nancy
CHEUNG, Atwood Kim
description The present invention provides a compound of formula (1) or a pharmaceutically acceptable salt thereof; N'R1 R4 i wherein R 1 R2 , R 4 and X 1 are defeined herein, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title HETEROARYL SUBSTITUTED SPIROPIPERIDINYL DERIVATIVES AND PHARMACEUTICAL USES THEREOF
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