TARGETED DELIVERY TO SCHWANN CELLS AND TREATMENT METHODS IN SCHWANN CELL-RELATED DISEASES

Disclosed herein are drug conjugates comprising targeting moieties conjugated to drug molecules, wherein the targeting moieties bind to receptors expressed on Schwann cells to mediate targeted delivery of the drug conjugate to the Schwann cell, and wherein the drug molecules modify expression or act...

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Bibliographische Detailangaben
Hauptverfasser:	BOGIN, Oren, EPSTEIN-BARASH, Hila, AZMON, Barak, ALSTER, Yair
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed herein are drug conjugates comprising targeting moieties conjugated to drug molecules, wherein the targeting moieties bind to receptors expressed on Schwann cells to mediate targeted delivery of the drug conjugate to the Schwann cell, and wherein the drug molecules modify expression or activity of disease-associated molecules in the Schwann cells. Further disclosed herein are methods of targeted delivery of a drug to the Schwann cells.