Polycyclic TLR7/8 antagonists and use thereof in the treatment of immune disorders
x t(R5) N (R')r n(R2) A B (R3)p (R)k (I) The present invention relates to compounds of Formula (I) and pharmaceutically acceptable compositions thereof, useful as toll-like receptor 7/8 (TLR7/8) antagonists. In Formula (I), Ring A is aryl or heteroaryl; Ring B is aryl or heteroaryl; and X is C(...
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| creator | BRUGGER, Nadia SHERER, Brian A |
| description | x t(R5) N (R')r n(R2) A B (R3)p (R)k (I) The present invention relates to compounds of Formula (I) and pharmaceutically acceptable compositions thereof, useful as toll-like receptor 7/8 (TLR7/8) antagonists. In Formula (I), Ring A is aryl or heteroaryl; Ring B is aryl or heteroaryl; and X is C(R4 ) 2 , 0, NR4 , S, S(R4 ), or S(R4 ) 2 . 20431589_1 (GHMatters) P108799.AU.2 |
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In Formula (I), Ring A is aryl or heteroaryl; Ring B is aryl or heteroaryl; and X is C(R4 ) 2 , 0, NR4 , S, S(R4 ), or S(R4 ) 2 . 20431589_1 (GHMatters) P108799.AU.2</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240118&DB=EPODOC&CC=AU&NR=2023285714A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240118&DB=EPODOC&CC=AU&NR=2023285714A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BRUGGER, Nadia</creatorcontrib><creatorcontrib>SHERER, Brian A</creatorcontrib><title>Polycyclic TLR7/8 antagonists and use thereof in the treatment of immune disorders</title><description>x t(R5) N (R')r n(R2) A B (R3)p (R)k (I) The present invention relates to compounds of Formula (I) and pharmaceutically acceptable compositions thereof, useful as toll-like receptor 7/8 (TLR7/8) antagonists. 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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Polycyclic TLR7/8 antagonists and use thereof in the treatment of immune disorders |
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