Polycyclic TLR7/8 antagonists and use thereof in the treatment of immune disorders

x t(R5) N (R')r n(R2) A B (R3)p (R)k (I) The present invention relates to compounds of Formula (I) and pharmaceutically acceptable compositions thereof, useful as toll-like receptor 7/8 (TLR7/8) antagonists. In Formula (I), Ring A is aryl or heteroaryl; Ring B is aryl or heteroaryl; and X is C(...

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Bibliographische Detailangaben
Hauptverfasser:	BRUGGER, Nadia, SHERER, Brian A
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	x t(R5) N (R')r n(R2) A B (R3)p (R)k (I) The present invention relates to compounds of Formula (I) and pharmaceutically acceptable compositions thereof, useful as toll-like receptor 7/8 (TLR7/8) antagonists. In Formula (I), Ring A is aryl or heteroaryl; Ring B is aryl or heteroaryl; and X is C(R4 ) 2 , 0, NR4 , S, S(R4 ), or S(R4 ) 2 . 20431589_1 (GHMatters) P108799.AU.2