BICYCLIC-SUBSTITUTED GLUTARIMIDE CEREBLON BINDERS

BICYCLIC-SUBSTITUTED GLUTARIMIDE CEREBLON BINDERS

This invention provides Degron compounds which bind to cereblon which is a component of the E3 ubiquitin ligase. The Degrons provided herein can be used to modulate the activity of cereblon either alone or as covalently linked to a Tail. Alternatively, the Degron can be linked to a Targeting Ligand...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: GOOD, Andrew, ERON, Scott, NASVESCHUK, Christopher, LIANG, Yanke, LAZARSKI, Kiel, HIRD, Alexander, VEITS, Gesine, HUANG, Hongwei, YIN, Ning
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:This invention provides Degron compounds which bind to cereblon which is a component of the E3 ubiquitin ligase. The Degrons provided herein can be used to modulate the activity of cereblon either alone or as covalently linked to a Tail. Alternatively, the Degron can be linked to a Targeting Ligand which binds to a Target Protein for protein degradation.