Prodrugs of 4'-C-substituted-2-halo-2'-deoxyadenosine nucleosides and methods of making and using the same

Prodrugs of 4'-C-substituted-2-halo-2'-deoxyadenosine nucleosides and methods of making and using the same

Abstract The present disclosure provides prodrugs of 4'-C-substituted-2-halo-2'-deoxyadenosidenucleosides, and compositions, methods and kits thereof. Such compounds can be useful for treating viral infections including, human immunodeficiency virus. The compounds have the following formul...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: NADUTHAMBI, Devan, BYUN, Daniel H, JANSA, Petr, MACKMAN, Richard L, CHUN, Byoung-Kwon, CLARKE, Michael O, SQUIRES, Neil H
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Beschreibung
Zusammenfassung:Abstract The present disclosure provides prodrugs of 4'-C-substituted-2-halo-2'-deoxyadenosidenucleosides, and compositions, methods and kits thereof. Such compounds can be useful for treating viral infections including, human immunodeficiency virus. The compounds have the following formula (1).