INTRAVASCULAR TREATMENT OF VASCULAR OCCLUSION AND ASSOCIATED DEVICES, SYSTEMS, AND METHODS

Abstract The invention relates to a method of treating deep vein thrombosis in a peripheral vasculature of a patient. The method comprises percutaneously accessing a venous vessel of a patient with an introducer sheath through an access site into the venous vessel of the patient; inserting a catheter constraining a thrombus extraction device through a lumen of the introducer sheath to proximate the vascular thrombus in the venous vessel, wherein the thrombus extraction device comprises a proximal self-expanding coring portion having a substantially unobstructed flow path and a distal expandable tubular portion formed of a mesh structure, wherein a proximal end of the mesh structure is coupled to a distal end of the coring portion, wherein a proximal end of the coring portion is coupled to a distal end of a first of the catheter, and wherein a distal end of the mesh structure is coupled to a distal end of a second shaft of the catheter that extends at least partially through the first shaft; deploying the thrombus extraction device from the catheter from a constrained configuration to an expanded configuration until the coring portion of the thrombus extraction device is beyond a distal end of the catheter; retracting the thrombus extraction device proximally so that the coring portion cores and separates the portion of the vascular thrombus from a venous vessel wall while the mesh structure captures the vascular thrombus portion; and withdrawing the thrombus extraction device from the patient. WO 2017/070702 PCT/US2016/058536 IIC) CNJt (c0 CNcJ