AZOLO COMPOUNDS FOR TREATMENT OF FIBROTIC DISEASES

The present invention relates to an azolo compound of Formula (I) for use in the treatment of fibrosis, wherein the azolo compounds normalizes collagen I mRNA-levels of TGFB-activated fibroblasts and reverses collagen production to the normal levels that are seen in fibroblasts that are not stimulat...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	VOSS, Edgar, HASENFUSS, Gerd, NYAMSUREN, Gunsmaa, TIETZE, Lutz Friedjahn, MOTHUKU, Shyam Sundar, ZEISBERG, Michael
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to an azolo compound of Formula (I) for use in the treatment of fibrosis, wherein the azolo compounds normalizes collagen I mRNA-levels of TGFB-activated fibroblasts and reverses collagen production to the normal levels that are seen in fibroblasts that are not stimulated.