LONG-ACTING SUSTAINED-RELEASE PREPARATION CONTAINING PRAMIPEXOLE AND PREPARATION METHOD THEREFOR

Disclosed is a long-acting sustained-release preparation pharmaceutical composition containing pramipexole, comprising a pharmaceutically acceptable salt of pramipexole and a pharmaceutical high polymer material. The preparation is selected from a microsphere, a sustained-release particle, and a sub...

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Bibliographische Detailangaben
Hauptverfasser:	SU, Zhengxing, CHEN, Zhihao, DING, Duohao, ZHAO, Dong
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed is a long-acting sustained-release preparation pharmaceutical composition containing pramipexole, comprising a pharmaceutically acceptable salt of pramipexole and a pharmaceutical high polymer material. The preparation is selected from a microsphere, a sustained-release particle, and a subcutaneous implant. The pharmaceutically acceptable salt of pramipexole is selected from erucate, stearate, oleate, α-linolenate, heptadecanoate, embonate, and palmitate. The high polymer material is selected from PLGA, PLA, mPEG-PLA, and PEG-PLA-PEG. The present invention belongs to the technical field of pharmaceutical preparations and solves the problems of short release period and poor release effect of pramipexole in the prior art.