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The present invention addresses the problem of providing a medicine capable of treating and/or preventing a disease associated with oxidative stress through the inhibition of a protein-protein interaction between Keap1 and Nrf2 to activate Nrf2. The present invention relates to a compound represente...
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Format: | Patent |
Sprache: | eng |
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Zusammenfassung: | The present invention addresses the problem of providing a medicine capable of treating and/or preventing a disease associated with oxidative stress through the inhibition of a protein-protein interaction between Keap1 and Nrf2 to activate Nrf2. The present invention relates to a compound represented by general formula (1): [wherein each symbol is as described in the description] or a pharmaceutically acceptable salt thereof. The present invention also relates to a medicine for preventing and/or treating a disease associated with oxidative stress, in which the disease is selected from the group consisting of chronic kidney disease, non-alcoholic fatty liver disease, chronic obstructive pulmonary disease, radiation-induced skin damages, radiation-induced mucosal damages, heart failure, pulmonary arterial hypertension, Parkinson's disease, Friedreich's ataxia, multiple sclerosis, age-related macular degeneration, retinitis pigmentosa and glaucoma, and the medicine contains the compound. |
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