Tablet formulation for CGRP-active compounds

Colloidal Silica (Cob-0-Sil)_ Cosieve Microcrystalne Cellulose (Aicel) Milled disperson Screen (optional) Manoitol NaCl Powder Crocarmellose Sodum Blend/Lubricate Coseved Cob-O-Sil/Avicel Sodium Stearyl Funarate Compress to Tablet The present invention is directed to compositions comprising an extmd...

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Bibliographische Detailangaben
Hauptverfasser:	W. Mark EICKHOFF, Chad D. BROWN, Paresh B. PATEL, Rebecca NOFSINGER, Francis J. FLANAGAN Jr, Melanie MAROTA, Craig B. IKEDA, Mary Ann JOHNSON, Lisa LUPTON, Leonardo Resende ALLAIN, Hanmi XI, Wei XU
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	Colloidal Silica (Cob-0-Sil)_ Cosieve Microcrystalne Cellulose (Aicel) Milled disperson Screen (optional) Manoitol NaCl Powder Crocarmellose Sodum Blend/Lubricate Coseved Cob-O-Sil/Avicel Sodium Stearyl Funarate Compress to Tablet The present invention is directed to compositions comprising an extmdate or solid solution of a compound, or a salt thereof, of Formula I (API): Formula I, wherein "Ra" is independently H or -F, in a water-soluble polymer matrix which further comprises a disintegration system allowing a tablet made therefrom to rapidly disintegrate in the environment in which the API is to be released.