SYNTHESIS OF ISOMERICALLY PURE POLYOL-BASED PHOSPHORAMIDITES

The present disclosure relates to a process for the regiochemically and enantiomerically controlled synthesis of phosphoramidite-containing monomers, and to intermediate products of this process. In some embodiments, the phosphoramidite-containing monomers or their precursors are regioisomerically a...

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Bibliographische Detailangaben
Hauptverfasser: KUCHELMEISTER, Hannes, BANASIK, Brent, SIMONYIOVA, Sona, TABONE, John C, PFAFFENEDER, Toni, JACOBS, Aaron, JUD, Lukas, DIAZ CORRAL, Julian Andres, NABAVI, Melud, THUER, Wilma
Format: Patent
Sprache:eng
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Zusammenfassung:The present disclosure relates to a process for the regiochemically and enantiomerically controlled synthesis of phosphoramidite-containing monomers, and to intermediate products of this process. In some embodiments, the phosphoramidite-containing monomers or their precursors are regioisomerically and/or enantiomerically pure and may be polymerized into polymers or copolymers.