FORMULATIONS COMPOSED OF CATIONIC LIPIDS AND POLY(LACTIC-CO-GLYCOLIC ACID) FOR THE DELIVERY OF POLYNUCLEOTIDES INTO CELLS

The present invention refers to a polynucleotide delivery particle, comprising a) at least one poly(lactic-co-glycolide); b) at least one cationic surfactant; c) at least one polynucleotide; and d) optionally at least one additive; wherein the poly(lactic-co-glycolide) has a weight average molecular...

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Bibliographische Detailangaben
Hauptverfasser:	BÄR, Hans, WINDHAB, Norbert, BENEDIKT, Anne, BERNHARDT, Alexander, HELLER, Philipp
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention refers to a polynucleotide delivery particle, comprising a) at least one poly(lactic-co-glycolide); b) at least one cationic surfactant; c) at least one polynucleotide; and d) optionally at least one additive; wherein the poly(lactic-co-glycolide) has a weight average molecular weight Mw of 1000 to 9500 g/mol measured via gel permeation chromatography using polystyrene standards and chloroform. Furthermore, the present invention pertains to a method of forming the polynucleotide delivery particle according to the present invention, wherein the particle is formed by a nanoprecipitation or nanoemulsion method. Moreover, the present invention refers to an oral drug delivery composition or a parenteral drug delivery composition comprising at least one polynucleotide delivery particle according to the present invention as well as their use as a medicament.