POLYMERIC IRON BINDING COMPOSITIONS AND METHODS OF USE FOR TREATING DISEASES ASSOCIATED WITH EXCESS DAMAGING REACTIVE IRON

Disclosed herein are iron-chelating polymers for treatment of diseases with an iron-mediated pathology, said polymers comprising a reaction product of a first monomer unit and a second monomer units polymerized by a reversible addition-fragmentation chain transfer mechanism with the use of a suitabl...

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Hauptverfasser:	GUMBAU-BRISA, Roger, ANG, M. Trisha C, HOLBEIN, Bruce E
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY COMPOSITIONS BASED THEREON HUMAN NECESSITIES HYGIENE MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR CHEMICAL WORKING-UP
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creator	GUMBAU-BRISA, Roger ANG, M. Trisha C HOLBEIN, Bruce E
description	Disclosed herein are iron-chelating polymers for treatment of diseases with an iron-mediated pathology, said polymers comprising a reaction product of a first monomer unit and a second monomer units polymerized by a reversible addition-fragmentation chain transfer mechanism with the use of a suitable addition-fragmentation chain transfer agent, wherein: the first monomer unit is represented by Compound (I); wherein the second monomer unit is independently selected from the group consisting of 1- vinyl-2-pyrrolidone, acrylic acid, methyl methacrylate, N,N-dimethyl-acrylamide, ethyl methacrylate, N-vinyl imidazole and styrene; the iron-chelating polymer is dissolved in an aqueous medium; the iron-chelating polymer has a molecular weight prior to chelation of at least about 1500 Da; and the iron-chelating polymer comprises one or more intramolecular hexadentate ligands for chelating iron. The described polymers are useful in the treatment of diseases associates with excess reactive iron.
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Trisha C ; HOLBEIN, Bruce E</creatorcontrib><description>Disclosed herein are iron-chelating polymers for treatment of diseases with an iron-mediated pathology, said polymers comprising a reaction product of a first monomer unit and a second monomer units polymerized by a reversible addition-fragmentation chain transfer mechanism with the use of a suitable addition-fragmentation chain transfer agent, wherein: the first monomer unit is represented by Compound (I); wherein the second monomer unit is independently selected from the group consisting of 1- vinyl-2-pyrrolidone, acrylic acid, methyl methacrylate, N,N-dimethyl-acrylamide, ethyl methacrylate, N-vinyl imidazole and styrene; the iron-chelating polymer is dissolved in an aqueous medium; the iron-chelating polymer has a molecular weight prior to chelation of at least about 1500 Da; and the iron-chelating polymer comprises one or more intramolecular hexadentate ligands for chelating iron. 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Trisha C</creatorcontrib><creatorcontrib>HOLBEIN, Bruce E</creatorcontrib><title>POLYMERIC IRON BINDING COMPOSITIONS AND METHODS OF USE FOR TREATING DISEASES ASSOCIATED WITH EXCESS DAMAGING REACTIVE IRON</title><description>Disclosed herein are iron-chelating polymers for treatment of diseases with an iron-mediated pathology, said polymers comprising a reaction product of a first monomer unit and a second monomer units polymerized by a reversible addition-fragmentation chain transfer mechanism with the use of a suitable addition-fragmentation chain transfer agent, wherein: the first monomer unit is represented by Compound (I); wherein the second monomer unit is independently selected from the group consisting of 1- vinyl-2-pyrrolidone, acrylic acid, methyl methacrylate, N,N-dimethyl-acrylamide, ethyl methacrylate, N-vinyl imidazole and styrene; the iron-chelating polymer is dissolved in an aqueous medium; the iron-chelating polymer has a molecular weight prior to chelation of at least about 1500 Da; and the iron-chelating polymer comprises one or more intramolecular hexadentate ligands for chelating iron. 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The described polymers are useful in the treatment of diseases associates with excess reactive iron.</abstract><oa>free_for_read</oa></addata></record>
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subjects	CHEMISTRY COMPOSITIONS BASED THEREON HUMAN NECESSITIES HYGIENE MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR CHEMICAL WORKING-UP
title	POLYMERIC IRON BINDING COMPOSITIONS AND METHODS OF USE FOR TREATING DISEASES ASSOCIATED WITH EXCESS DAMAGING REACTIVE IRON
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