POLYMERIC IRON BINDING COMPOSITIONS AND METHODS OF USE FOR TREATING DISEASES ASSOCIATED WITH EXCESS DAMAGING REACTIVE IRON

Disclosed herein are iron-chelating polymers for treatment of diseases with an iron-mediated pathology, said polymers comprising a reaction product of a first monomer unit and a second monomer units polymerized by a reversible addition-fragmentation chain transfer mechanism with the use of a suitable addition-fragmentation chain transfer agent, wherein: the first monomer unit is represented by Compound (I); wherein the second monomer unit is independently selected from the group consisting of 1- vinyl-2-pyrrolidone, acrylic acid, methyl methacrylate, N,N-dimethyl-acrylamide, ethyl methacrylate, N-vinyl imidazole and styrene; the iron-chelating polymer is dissolved in an aqueous medium; the iron-chelating polymer has a molecular weight prior to chelation of at least about 1500 Da; and the iron-chelating polymer comprises one or more intramolecular hexadentate ligands for chelating iron. The described polymers are useful in the treatment of diseases associates with excess reactive iron.