IMPROVED IGG-DEGRADING ENZYMES AND METHODS OF USE THEREOF

Provided are improved cysteine proteases for specifically cleaving and inactivating immunoglobulin G. The improved cysteine proteases are useful in methods of treating diseases, disorders or conditions characterized by excessive levels of IgG antibodies, including autoimmune disorders and candidates...

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Bibliographische Detailangaben
Hauptverfasser:	GARDNER, Hannah Szydlo, LOHSE, Laura Lin, LIM, Kok Hong, TAM, Sze Pui, DEWAGE, Amendra Fernando Hewa, LAMEYER, Maria Paquerette Galou, JOYCE, Alison Patricia, MYERS, Alyssa Ann, KING, Amy Cotsonas, MURPHY, Denise Mary, MARZE, Nicholas Andrew, BRODFUEHRER, Joanne Irene
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided are improved cysteine proteases for specifically cleaving and inactivating immunoglobulin G. The improved cysteine proteases are useful in methods of treating diseases, disorders or conditions characterized by excessive levels of IgG antibodies, including autoimmune disorders and candidates for organ transplantation sensitized with anti-HLA antibodies, as well as for treating candidates for gene therapy with pre-existing neutralizing antibodies against recombinant vectors and re-dosing of subjects previously treated with a gene therapy vector.