Anticancer drugs and methods of making and using same

Anticancer drugs and methods of making and using same

Abstract The present invention provides drug modifications for improving biodistribution and/or specificity of an anticancer drug. In certain embodiments, the compound of the invention comprises a drug, a linker, and a core acid. The core acid can be varied to tune the properties of the compound wit...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: HUNGERFORD, William, SPIEGEL, David, WANGWEERAWONG, Apiwat, ENGELMAN, Donald, SABBASANI, Venkatareddy, WANG, Kung-Pern, HOYER, Denton, DEACON, John
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Abstract The present invention provides drug modifications for improving biodistribution and/or specificity of an anticancer drug. In certain embodiments, the compound of the invention comprises a drug, a linker, and a core acid. The core acid can be varied to tune the properties of the compound within the body, such that the compound would selectively distributes to tumours and is, or becomes, active in the cytosol.