NUCLEIC ACID-GUIDED NICKASE FUSION PROTEINS

This disclosure provides compositions and methods useful for editing a target nucleic acid molecule. This disclosure provides MAD2019-H848A variant polypeptides, reverse transcriptases, and fusion proteins and methods of using MAD2019-H848A variant polypeptides, reverse transcriptases, and fusion pr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: KIM, Juhan, MIJTS, Benjamin
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:This disclosure provides compositions and methods useful for editing a target nucleic acid molecule. This disclosure provides MAD2019-H848A variant polypeptides, reverse transcriptases, and fusion proteins and methods of using MAD2019-H848A variant polypeptides, reverse transcriptases, and fusion proteins to edit nucleic acid molecules both