FUSED HETEROARYL HYDROXAMATES AS STING AGONISTS

The invention provides novel substituted heterocyclic compounds represented by the Formulas (I), or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as agonists of Stimulator o...

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Hauptverfasser: YOON, Cheolhwan, KIM, Sunjoo, LEE, Jungwoo, SEO, Jeongbeob, HAN, Cheolkyu, JEON, Sunhwa, JEON, Seeun, LEE, Jinwoo, YANG, Inho, KANG, Hongjun, KANG, Byungnam, SHIN, Youngdo
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creator YOON, Cheolhwan
KIM, Sunjoo
LEE, Jungwoo
SEO, Jeongbeob
HAN, Cheolkyu
JEON, Sunhwa
JEON, Seeun
LEE, Jinwoo
YANG, Inho
KANG, Hongjun
KANG, Byungnam
SHIN, Youngdo
description The invention provides novel substituted heterocyclic compounds represented by the Formulas (I), or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as agonists of Stimulator of Interferon Genes (STING) and are useful in the treatment of cancers and certain infectious diseases.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title FUSED HETEROARYL HYDROXAMATES AS STING AGONISTS
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