PD-1/PD-L1 inhibitors

Abstract Substituted heterocyclic compounds of formula I and their salts, stereoisomers or tautomers thereof are disclosed. Methods of using compounds of formula I singly or in combination with additional agents as well as compositions are further disclosed. Compounds of formula I are shown to be in...

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Bibliographische Detailangaben
Hauptverfasser:	GRAUPE, Michael, PARKHILL, Eric Q, WANG, Peiyuan, WATKINS, William J, NADUTHAMBI, Devan, METOBO, Samuel E, CHO, Aesop, MUKHERJEE, Prasenjit Kumar, DU, Zhimin, ZIEBENHAUS, Christopher Allen, MEDLEY, Jonathan William, AKTOUDIANAKIS, Evangelos, LAD, Lateshkumar Thakorlal, XU, Jie, MACHICAO TELLO, Paulo A, PHILLIPS, Barton W, SQUIRES, Neil H, YANG, Kin Shing, SIMONOVICH, Scott Preston
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Abstract Substituted heterocyclic compounds of formula I and their salts, stereoisomers or tautomers thereof are disclosed. Methods of using compounds of formula I singly or in combination with additional agents as well as compositions are further disclosed. Compounds of formula I are shown to be inhibitors of programmed death 1 (PD-1). Compounds of formula I can be used in, for example, the treatment of cancer.