Methods for treating Arenaviridae and Coronaviridae virus infections

Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: 0 ' O- O N NR9 wherein the ' position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularl...

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Bibliographische Detailangaben
Hauptverfasser:	Mackman, Richard L, Feng, Joy Yang, Clarke, Michael O'Neil Hanrahan, Siegel, Dustin, Jordan, Robert, Ray, Adrian S
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: 0 ' O- O N NR9 wherein the ' position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.