Complex of gadolinium and a chelating ligand derived of a diastereoisomerically enriched PCTA and synthesis method

The present invention relates to a complex of formula (II) constituted of at least 80% of a diastereoisomeric excess comprising a mixture of isomers l1-RRR and II-SSS of formulae: S O O NH OH 0 N---d- -- -N OH (ii-SSS) N--Gd-- -N 0.0 HO HN O H (II-RRR) The present invention also relates to a process...

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Bibliographische Detailangaben
Hauptverfasser:	Cerf, Martine, François, Bruno, Chénedé, Alain, Decron, Stéphane, Le Greneur, Soizic
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates to a complex of formula (II) constituted of at least 80% of a diastereoisomeric excess comprising a mixture of isomers l1-RRR and II-SSS of formulae: S O O NH OH 0 N---d- -- -N OH (ii-SSS) N--Gd-- -N 0.0 HO HN O H (II-RRR) The present invention also relates to a process for preparing said complex of formula (II), and also to two synthetic intermediates.