INTRACELLULAR DELIVERY COMPOSITIONS

INTRACELLULAR DELIVERY COMPOSITIONS

Protein conjugates comprising a protein carrier comprising a plurality of amine groups, a biological payload that interacts with an intracellular target and a linker linking them, wherein at least a portion of the amine groups are bound to a protecting group are provided. Pharmaceutical compositions...

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Bibliographische Detailangaben
Hauptverfasser: HAKIM, Motti, FAYGENBOIM-ORNAI, Rotem, GOTTFRIED, Yossi, EYLON, Bat-Hen, SAPIR, Yair, MANDEL, Ilana, SHULMAN, Avidor, SHILOVITZKY, Orit, LEWKOWICZ, Ayala, CHEN ZELTSBURG, Lilach, UZAN GUETA, Rozi Ravit, FREILICH, Shay, BEN-MOSHE, Tehila
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Protein conjugates comprising a protein carrier comprising a plurality of amine groups, a biological payload that interacts with an intracellular target and a linker linking them, wherein at least a portion of the amine groups are bound to a protecting group are provided. Pharmaceutical compositions comprising the protein conjugates as well as methods of using and producing the protein conjugates are also provided.