ANTISENSE OLIGONUCLEOTIDES

The present invention relates to novel antisense oligonucleotides comprising at least one modified nucleotide from among oligonucleotides of SEQ ID NOs: 1 to 3. The novel oligonucleotides exhibit an excellent effect of inhibiting the expression of TGF-β2 protein, an excellent effect of killing cance...

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Bibliographische Detailangaben
Hauptverfasser:	PARK, Jun Eui, HONG, Soo Jeong, KIM, Tae Hun, KIM, Ji-Hye, KWON, Hye Jeong, KOO, Ji Hye, PARK, Chang Hee
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to novel antisense oligonucleotides comprising at least one modified nucleotide from among oligonucleotides of SEQ ID NOs: 1 to 3. The novel oligonucleotides exhibit an excellent effect of inhibiting the expression of TGF-β2 protein, an excellent effect of killing cancer cells, and improved stability in plasma. Therefore, the oligonucleotides of the present invention can be effectively used as a pharmaceutical composition for treating diseases related to TGF-β2 expression.