BIOSYNTHETIC BIPARATOPIC OR BISPECIFIC BINDING MOLECULES WITH ENHANCED EFFECTOR FUNCTIONS

BIOSYNTHETIC BIPARATOPIC OR BISPECIFIC BINDING MOLECULES WITH ENHANCED EFFECTOR FUNCTIONS

Provided herein, in certain aspects, is a binding molecule comprising an antigen binding domain and an Fc region; wherein the antigen binding domain is biparatopic or bispecific and the Fc region comprises K248E and T437R mutations (RE mutations), wherein amino acid residue numbering is according to...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ZWOLAK, Adam, HANSEN, Michael Riis, SINGH, Sanjaya, TESTA, Jr, WHITE, Ian, LIN-SCHMIDT, Xiefan, HO, Jason
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Provided herein, in certain aspects, is a binding molecule comprising an antigen binding domain and an Fc region; wherein the antigen binding domain is biparatopic or bispecific and the Fc region comprises K248E and T437R mutations (RE mutations), wherein amino acid residue numbering is according to the EU numbering system; wherein the binding molecule has increased capability of hexamerization on a cell surface, and/or increased capability of engaging Clq.