ANTI-CD37 ANTIBODY-DRUG CONJUGATE

The present invention provides: an antibody that specifically binds to CD37-positive tumor cells such as B-cell malignant lymphoma; an antibody-drug conjugate that contains said antibody; a pharmaceutical composition that employs said antibody and that exhibits a therapeutic effect on a tumor; a tum...

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Bibliographische Detailangaben
Hauptverfasser:	SUGAWARA Hajime, SHUCHI Yusuke, TERAUCHI Tomoko, GOTO Riki, SHINJO Yuji
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides: an antibody that specifically binds to CD37-positive tumor cells such as B-cell malignant lymphoma; an antibody-drug conjugate that contains said antibody; a pharmaceutical composition that employs said antibody and that exhibits a therapeutic effect on a tumor; a tumor treatment method employing said pharmaceutical composition; a method for producing said antibody; a method for producing said antibody-drug conjugate; and so forth.　Provided is an anti-CD37 antibody-drug conjugate in which a drug linker, which is represented by the formula below, and an antibody are bonded by means of a thioether bond (in the formula, A indicates the position at which the linker is bonded with the antibody). Specifically, provided are: a humanized anti-CD37 antibody that exhibits an internalization activity; and an antibody-drug conjugate that contains said antibody.