CD28 SHEDDING BLOCKING AGENTS

Single domain antibodies (sdAbs) that block CD28 cleavage are provided. Dimeric agents at least two membranal CD28 binding agents are also provided, as are methods of using the sdAbs and/or dimeric agents and pharmaceutical compositions and kits comprising the sdAbs and/or dimeric agents.

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Bibliographische Detailangaben
Hauptverfasser: LEWKOWICZ, Ayala, HAKIM, Motti, FRIDMAN-DROR, Anna, CHEN ZELTSBURG, Lilach, MANDEL, Ilana, SAPIR, Yair, SHULMAN, Avidor, BEN-MOSHE, Tehila, GABAY, Tal
Format: Patent
Sprache:eng
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Zusammenfassung:Single domain antibodies (sdAbs) that block CD28 cleavage are provided. Dimeric agents at least two membranal CD28 binding agents are also provided, as are methods of using the sdAbs and/or dimeric agents and pharmaceutical compositions and kits comprising the sdAbs and/or dimeric agents.