MIXED LINEAGE KINASE INHIBITORS AND METHODS OF USE

MIXED LINEAGE KINASE INHIBITORS AND METHODS OF USE

Mixed lineage kinase (MLK) inhibitors are disclosed. The compounds inhibit kinase activity. The compounds may be used to treat diseases or conditions characterized at least in part by overexpression of one or more MLKs. The compounds have a structure according to formula I, or a stereoisomer, tautom...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SWENSON, Rolf E, KATERJI, Meghri, BROGNARD, John F, NYSWANER, Katherine M, SABBASANI, Venkatareddy, CAPPELL, Steven D, BERGMAN, Knickole L, FUNK, Amy L, HITKO, Carolyn W, LINDBERG, Eric
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Mixed lineage kinase (MLK) inhibitors are disclosed. The compounds inhibit kinase activity. The compounds may be used to treat diseases or conditions characterized at least in part by overexpression of one or more MLKs. The compounds have a structure according to formula I, or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof.